8eww: Difference between revisions

Latest revision as of 18:01, 29 May 2024

Structure of Arabidopsis fatty acid amide hydrolase mutant S305A

Structural highlights

8eww is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FAAH_ARATH Degrades bioactive fatty acid amides to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Converts N-actylethanolamine (NAE) to ethanolamine. Can also use oleamide or 2-arachidonylglycerol as substrates, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine. Might be involved in abscisic acid signaling and plant defense through distinctly different mechanisms not involving the catalytic activity.^[1] ^[2] ^[3] ^[4]

References

↑ Shrestha R, Dixon RA, Chapman KD. Molecular identification of a functional homologue of the mammalian fatty acid amide hydrolase in Arabidopsis thaliana. J Biol Chem. 2003 Sep 12;278(37):34990-7. Epub 2003 Jun 24. PMID:12824167 doi:https://dx.doi.org/10.1074/jbc.M305613200
↑ Wang YS, Shrestha R, Kilaru A, Wiant W, Venables BJ, Chapman KD, Blancaflor EB. Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12197-202. doi:, 10.1073/pnas.0603571103. Epub 2006 Jul 31. PMID:16880402 doi:https://dx.doi.org/10.1073/pnas.0603571103
↑ Kang L, Wang YS, Uppalapati SR, Wang K, Tang Y, Vadapalli V, Venables BJ, Chapman KD, Blancaflor EB, Mysore KS. Overexpression of a fatty acid amide hydrolase compromises innate immunity in Arabidopsis. Plant J. 2008 Oct;56(2):336-349. doi: 10.1111/j.1365-313X.2008.03603.x. Epub 2008, Jul 4. PMID:18643971 doi:https://dx.doi.org/10.1111/j.1365-313X.2008.03603.x
↑ Kim SC, Kang L, Nagaraj S, Blancaflor EB, Mysore KS, Chapman KD. Mutations in Arabidopsis fatty acid amide hydrolase reveal that catalytic activity influences growth but not sensitivity to abscisic acid or pathogens. J Biol Chem. 2009 Dec 4;284(49):34065-74. doi: 10.1074/jbc.M109.059022. Epub 2009, Sep 30. PMID:19801664 doi:https://dx.doi.org/10.1074/jbc.M109.059022

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Shrestha R, Dixon RA, Chapman KD. Molecular identification of a functional homologue of the mammalian fatty acid amide hydrolase in Arabidopsis thaliana. J Biol Chem. 2003 Sep 12;278(37):34990-7. Epub 2003 Jun 24. PMID:12824167 doi:https://dx.doi.org/10.1074/jbc.M305613200

[2] Wang YS, Shrestha R, Kilaru A, Wiant W, Venables BJ, Chapman KD, Blancaflor EB. Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12197-202. doi:, 10.1073/pnas.0603571103. Epub 2006 Jul 31. PMID:16880402 doi:https://dx.doi.org/10.1073/pnas.0603571103

[3] Kang L, Wang YS, Uppalapati SR, Wang K, Tang Y, Vadapalli V, Venables BJ, Chapman KD, Blancaflor EB, Mysore KS. Overexpression of a fatty acid amide hydrolase compromises innate immunity in Arabidopsis. Plant J. 2008 Oct;56(2):336-349. doi: 10.1111/j.1365-313X.2008.03603.x. Epub 2008, Jul 4. PMID:18643971 doi:https://dx.doi.org/10.1111/j.1365-313X.2008.03603.x

[4] Kim SC, Kang L, Nagaraj S, Blancaflor EB, Mysore KS, Chapman KD. Mutations in Arabidopsis fatty acid amide hydrolase reveal that catalytic activity influences growth but not sensitivity to abscisic acid or pathogens. J Biol Chem. 2009 Dec 4;284(49):34065-74. doi: 10.1074/jbc.M109.059022. Epub 2009, Sep 30. PMID:19801664 doi:https://dx.doi.org/10.1074/jbc.M109.059022

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8eww is ON HOLD  until Paper Publication
+==Structure of Arabidopsis fatty acid amide hydrolase mutant S305A==
+<StructureSection load='8eww' size='340' side='right'caption='[[8eww]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors: Aziz, M., Wang, X., Gaguancela, O.A., Chapman, K.D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8eww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EWW FirstGlance]. <br>
-Description: Structure of Arabidopsis fatty acid amide hydrolase mutant S305A
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eww OCA], [https://pdbe.org/8eww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eww RCSB], [https://www.ebi.ac.uk/pdbsum/8eww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eww ProSAT]</span></td></tr>
-[[Category: Gaguancela, O.A]]
+</table>
-[[Category: Chapman, K.D]]
+== Function ==
-[[Category: Wang, X]]
+[https://www.uniprot.org/uniprot/FAAH_ARATH FAAH_ARATH] Degrades bioactive fatty acid amides to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Converts N-actylethanolamine (NAE) to ethanolamine. Can also use oleamide or 2-arachidonylglycerol as substrates, but not indole-3-acetamide, 1-naphtalene-acetamide, nicotinic acid amide or L-asparagine. Might be involved in abscisic acid signaling and plant defense through distinctly different mechanisms not involving the catalytic activity.<ref>PMID:12824167</ref> <ref>PMID:16880402</ref> <ref>PMID:18643971</ref> <ref>PMID:19801664</ref>
-[[Category: Aziz, M]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Large Structures]]
+[[Category: Aziz M]]
+[[Category: Chapman KD]]
+[[Category: Gaguancela OA]]
+[[Category: Wang X]]

8eww: Difference between revisions

Latest revision as of 18:01, 29 May 2024

Structure of Arabidopsis fatty acid amide hydrolase mutant S305A

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools