8h0n: Difference between revisions
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New page: '''Unreleased structure''' The entry 8h0n is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures |
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The entry | ==Crystal structure of the human METTL1-WDR4 complex== | ||
<StructureSection load='8h0n' size='340' side='right'caption='[[8h0n]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8h0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H0N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h0n OCA], [https://pdbe.org/8h0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h0n RCSB], [https://www.ebi.ac.uk/pdbsum/8h0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h0n ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/WDR4_HUMAN WDR4_HUMAN] Galloway-Mowat syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/WDR4_HUMAN WDR4_HUMAN] Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069).<ref>PMID:12403464</ref> <ref>PMID:26751069</ref> <ref>PMID:31031083</ref> <ref>PMID:31031084</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gong Z]] | |||
[[Category: Guan ZY]] | |||
[[Category: Jin XH]] | |||
[[Category: Zhang DL]] | |||
Latest revision as of 05:46, 5 July 2023
Crystal structure of the human METTL1-WDR4 complex
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