8f65: Difference between revisions
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==Crystal structure of VACV D13 in complex with BBL030900== | |||
<StructureSection load='8f65' size='340' side='right'caption='[[8f65]], [[Resolution|resolution]] 2.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8f65]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F65 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=QF6:8-methoxyquinolin-4-amine'>QF6</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f65 OCA], [https://pdbe.org/8f65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f65 RCSB], [https://www.ebi.ac.uk/pdbsum/8f65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f65 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/PG125_VACCW PG125_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of OPG158 N-terminus.<ref>PMID:19570860</ref> <ref>PMID:35361762</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vaccinia virus]] | |||
[[Category: Coulibaly F]] | |||
[[Category: Garriga D]] | |||
[[Category: Subedi BP]] | |||
Latest revision as of 09:49, 4 March 2026
Crystal structure of VACV D13 in complex with BBL030900
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