Sandbox Q123: Difference between revisions

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== Structural insights ==

<scene name='43/~~430871~~/Cv/3'>Fibronectin (FN) is a dimer of homologous monomers~~</scene>~~ linked by S-S bond. Each monomer contains 3 types of repeating units: FN I, FN II and FN III. Type I and type II repeats are disulfide-bonded loops, containing about 45 and 60 amino-acids each, while type III repeats are about 90 amino-acids long without S-S bonds<ref name="Pancov">PMID:12244123</ref><ref name="Proctor">PMID:3326130</ref><ref name="Richard">PMID:3916323</ref>. Each module contains several numbered protein binding domains, i.e., FN I~~~~6~~-~~FN II~~~~1-2~~-~~FN I~~~~7-9~~~~ is the gelatin binding domain (GBD).

<scene name='93/932569/Fn/6'>Fibronectin (FN)</scene> is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of repeating units: <scene name='93/932569/Fn_i/2'>FN I</scene>, <scene name='93/932569/Fn_ii/3'>FN II</scene> and <scene name='93/932569/Fn_iii/3'>FN III</scene>. Type I and type II repeats are disulfide-bonded loops, containing about 45 and 60 amino-acids each, while type III repeats are about 90 amino-acids long without S-S bonds<ref name="Pancov">PMID:12244123</ref><ref name="Proctor">PMID:3326130</ref><ref name="Richard">PMID:3916323</ref>. Each module contains several numbered protein binding domains, i.e., the region containing FN I repeat 6, FN II repeat 1-2 and FN I repeat 7-9 is the gelatin binding domain (GBD).

== Biological Functions ==

Sandbox Q123: Difference between revisions

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-<StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
+<StructureSection load='' size='350' side='right' scene='93/932569/Fn/6' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
 == Structural insights ==
-<scene name='43/430871/Cv/3'>Fibronectin (FN) is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of repeating units: FN I, FN II and FN III. Type I and type II repeats are disulfide-bonded loops, containing about 45 and 60 amino-acids each, while type III repeats are about 90 amino-acids long without S-S bonds<ref name="Pancov">PMID:12244123</ref><ref name="Proctor">PMID:3326130</ref><ref name="Richard">PMID:3916323</ref>. Each module contains several numbered protein binding domains, i.e., FN I<sub>6</sub>-FN II<sub>1-2</sub>-FN I<sub>7-9</sub> is the gelatin binding domain (GBD).
+<scene name='93/932569/Fn/6'>Fibronectin (FN)</scene> is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of repeating units: <scene name='93/932569/Fn_i/2'>FN I</scene>, <scene name='93/932569/Fn_ii/3'>FN II</scene> and <scene name='93/932569/Fn_iii/3'>FN III</scene>. Type I and type II repeats are disulfide-bonded loops, containing about 45 and 60 amino-acids each, while type III repeats are about 90 amino-acids long without S-S bonds<ref name="Pancov">PMID:12244123</ref><ref name="Proctor">PMID:3326130</ref><ref name="Richard">PMID:3916323</ref>. Each module contains several numbered protein binding domains, i.e., the region containing FN I repeat 6, FN II repeat 1-2 and FN I repeat 7-9 is the gelatin binding domain (GBD).
 == Biological Functions ==