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'''Unreleased structure'''


The entry 8bpb is ON HOLD  until sometime in the future
==Cryo-EM structure of the human SIN3B histone deacetylase core complex at 2.8 Angstrom==
<StructureSection load='8bpb' size='340' side='right'caption='[[8bpb]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8bpb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpb OCA], [https://pdbe.org/8bpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpb RCSB], [https://www.ebi.ac.uk/pdbsum/8bpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] SIN3A-related intellectual disability syndrome due to a point mutation.
== Function ==
[https://www.uniprot.org/uniprot/SIN3B_HUMAN SIN3B_HUMAN] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141]


Authors:  
==See Also==
 
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
Description:  
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alfieri C]]
[[Category: Koliopolous MG]]
[[Category: Muhammad R]]
[[Category: Wan MSM]]
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