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| == Function == | | == Function == |
| '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. | | '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. |
| | *'''Contactin-2''' is a synaptic membrane protein involved in pathology of Alzheimer Disease<ref>PMID:29859129</ref>. |
| | *'''Contactin-4''' ,''' contactin-5''' and '''contactin-6''' are involved in brain developmen<ref>PMID:23519440</ref>. |
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| == Disease == | | == Disease == |
| contactin-4 is an autism susceptibility locus<ref>PMID:21308999</ref>. | | Mutations in contactin-4, contactin-5 and contactin-6 confer risk of autism <ref>PMID:21308999</ref>. |
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| </StructureSection> | | </StructureSection> |
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| **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | | **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> |
| **[[2ee2]] – hCNTN FN3 domains - NMR <br /> | | **[[2ee2]] – hCNTN FN3 domains 798-903 - NMR <br /> |
| **[[5e53]] – cCNTN FN1-FN3 domains – chicken <br /> | | **[[7ol2]] – mCNTN Ig1-Ig6 domains 28-608 - mouse <br /> |
| | **[[5e53]] – cCNTN FN1-FN3 domains 601-893 – chicken <br /> |
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| * Contactin-2 | | * Contactin-2 |
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| **[[2om5]] – hCNTN Ig1-Ig4 domains <br /> | | **[[8k53]], [[9ba4]] – hCNTN – Cryo EM <br /> |
| **[[5e7l]] – mCNTN FN1-FN3 domains – mouse <br/ > | | **[[2om5]] – hCNTN Ig1-Ig4 domains 34-414 <br /> |
| | **[[8k3j]] – hCNTN Ig1-Ig6<br /> |
| | **[[9ba5]] – hCNTN Ig1-Ig6 – Cryo EM<br /> |
| | **[[5e7l]] – mCNTN FN1-FN3 domains 609-911 <br/ > |
| | **[[8a0y]] – mCNTN Ig1-Ig6 domains 28-608 <br /> |
| | **[[7ol4]] – mCNTN Ig1-Ig6 domains + neurofascin<br /> |
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| * Contactin-3 | | * Contactin-3 |
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Function
Contactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems[1].
- Contactin-2 is a synaptic membrane protein involved in pathology of Alzheimer Disease[2].
- Contactin-4 , contactin-5 and contactin-6 are involved in brain developmen[3].
Disease
Mutations in contactin-4, contactin-5 and contactin-6 confer risk of autism [4].
- ↑ Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:https://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
- ↑ Chatterjee M, Del Campo M, Morrema THJ, de Waal M, van der Flier WM, Hoozemans JJM, Teunissen CE. Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease. Alzheimers Res Ther. 2018 Jun 1;10(1):52. PMID:29859129 doi:10.1186/s13195-018-0383-x
- ↑ Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, De Chaumont F, Bourgeron T, Cloëz-Tayarani I. Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites. Biol Open. 2013 Mar 15;2(3):324-34. PMID:23519440 doi:10.1242/bio.20133343
- ↑ Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:https://dx.doi.org/10.1002/aur.184
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3D structures of contactin
Updated on 06-February-2025
{"openlevels":0}
- Contactin-1
- 3s97 – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human
- 2ee2 – hCNTN FN3 domains 798-903 - NMR
- 7ol2 – mCNTN Ig1-Ig6 domains 28-608 - mouse
- 5e53 – cCNTN FN1-FN3 domains 601-893 – chicken
- Contactin-2
- 8k53, 9ba4 – hCNTN – Cryo EM
- 2om5 – hCNTN Ig1-Ig4 domains 34-414
- 8k3j – hCNTN Ig1-Ig6
- 9ba5 – hCNTN Ig1-Ig6 – Cryo EM
- 5e7l – mCNTN FN1-FN3 domains 609-911
- 8a0y – mCNTN Ig1-Ig6 domains 28-608
- 7ol4 – mCNTN Ig1-Ig6 domains + neurofascin
- Contactin-3
- 5e4q – mCNTN FN1-FN3 domains
- 5i99 – mCNTN Ig5-FN2 domains
- 5e5r – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ
- 7mrm – cCNTN FN1-FN2 domains + APPb
- Contactin-4
- 5e4s – mCNTN FN1-FN3 domains
- 3jxa – mCNTN Ig1-Ig4 domains
- 3kld – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ
- 7mrq – cCNTN FN1-FN3 domains
- 7mro – zCNTN FN1-FN3 domains 600-903 – zebrafish
- 7mrk, 7mrs – zCNTN FN1-FN3 domains + APPb
- 7mqy – zCNTN FN1-FN3 domains + APLP2
- Contactin-5
- 5e52 – hCNTN FN1-FN3 domains
- 4n68 – hCNTN FN3 domains
- 5e4i – mCNTN Ig1-Ig4 domains 96-477
- 7mrn – mCNTN FN1-FN3 domains 669-970 + APP
- Contactin-6
- 5e55 – mCNTN FN1-FN3 domains
- 5e5u – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase gamma
References
