8gpn: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Human menin in complex with H3K79Me2 nucleosome== | |||
<StructureSection load='8gpn' size='340' side='right'caption='[[8gpn]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8gpn]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GPN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gpn OCA], [https://pdbe.org/8gpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gpn RCSB], [https://www.ebi.ac.uk/pdbsum/8gpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gpn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
*[[Menin|Menin]] | |||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Dang | [[Category: Large Structures]] | ||
[[Category: | [[Category: Xenopus laevis]] | ||
[[Category: Li | [[Category: Dang S]] | ||
[[Category: | [[Category: Lam WH]] | ||
[[Category: Li XD]] | |||
[[Category: Lin J]] | |||
[[Category: Yu D]] | |||
[[Category: Zhai Y]] | |||
Latest revision as of 11:28, 18 June 2025
Human menin in complex with H3K79Me2 nucleosome
| ||||||||||||
