8h7j: Difference between revisions
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The | ==The crystal structure of CD163 SRCR5-9== | ||
<StructureSection load='8h7j' size='340' side='right'caption='[[8h7j]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8h7j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H7J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h7j OCA], [https://pdbe.org/8h7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h7j RCSB], [https://www.ebi.ac.uk/pdbsum/8h7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h7j ProSAT]</span></td></tr> | ||
[[Category: Li | </table> | ||
[[Category: Luo | == Function == | ||
[https://www.uniprot.org/uniprot/C163A_PIG C163A_PIG] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Li R]] | |||
[[Category: Luo ZP]] | |||
[[Category: Ma HF]] | |||
Latest revision as of 07:05, 25 October 2023
The crystal structure of CD163 SRCR5-9
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