Sandbox Reserved 1739: Difference between revisions
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{{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
== Function == | == Function == | ||
HCV is | HCV is most closely related to the ''Flaviviridae'' family. These viruses have a NS3 serine protease that is necessary for replication, but it is not known why. HCV also has a NS2-3 serine protease that executes ''cis'' cleavage at the 2/3 site and is autocatalytic, unlike other RNA viruses that just utilize the NS3 serine protease (2). | ||
The function of Hepatitis C primase is to build the viral capsid. The viral capsid is built by forming alpha helices in areas with bactericide, and forming aggregates in areas that lack them. Assembly happens from interactions between dimers and endoplasmic reticulum, along with other oligomers, proteins, and lipid droplets. The viral capsid and two glycoproteins make up the genome (1). | The function of Hepatitis C primase is to build the viral capsid. The viral capsid is built by forming alpha helices in areas with bactericide, and forming aggregates in areas that lack them. Assembly happens from interactions between dimers and endoplasmic reticulum, along with other oligomers, proteins, and lipid droplets. The viral capsid and two glycoproteins make up the genome (1). | ||
The function of Hepatitis C helicase is to stop viral RNA from binding by stripping it of its proteins. It is necessary for viral replication (2). Helicase can process a wide range of nucleic acid sequences and unwind them (5). | The function of Hepatitis C helicase is to stop viral RNA from binding by stripping it of its proteins. It is necessary for viral replication (2). Helicase can process a wide range of nucleic acid sequences and unwind them (5). | ||
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Primary Structure: 620 amino acids. | Primary Structure: 620 amino acids. | ||
Secondary Structure: beta sheets sandwiched between Alpha helices. | Secondary Structure: beta sheets sandwiched between Alpha helices (12). | ||
Tertiary Structure: Domains: 3 domains; domain 2 is linked to domains 1 and 3 by flexible linkers. Motifs present: 6 motifs; the Walker A motif, the Phe loop, and the Arg-clamp motif (12). | Tertiary Structure: Domains: 3 domains; domain 2 is linked to domains 1 and 3 by flexible linkers. Motifs present: 6 motifs; the Walker A motif, the Phe loop, and the Arg-clamp motif (12). | ||
