Cytochrome P450: Difference between revisions
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== Function == | == Function == | ||
[[Cytochrome P450]] (P450) or '''cytochrome P450 monooxygenase''' catalyzes the oxidation of organic substances like lipids. | [[Cytochrome P450]] (P450) or '''cytochrome P450 monooxygenase''' catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> P450 CYP121 is called '''mycocyclosin synthase'''. | ||
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br /> | * '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor<ref>PMID:10698731</ref>.<br /> | ||
* '''P450nor''' is a Nitric Oxide Reductase P450.<br /> | * '''P450nor''' is a Nitric Oxide Reductase P450<ref>PMID:15598501</ref>.<br /> | ||
* '''P450epoK''' converts epothilone D to epothilone B.<br /> | * '''P450epoK''' converts epothilone D to epothilone B<ref>PMID:12933799</ref>.<br /> | ||
* '''P450cin''' monooxygenates 1,8-cineole which is similar to camphor.<br /> | * '''P450cin''' monooxygenates 1,8-cineole which is similar to camphor<ref>PMID:26002741</ref>.<br /> | ||
* '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br /> | * '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br /> | ||
* '''P450 3A4''' see [[CYP3A4]].<br /> | * '''P450 3A4''' see [[CYP3A4]].<br /> | ||
* '''P450 19 family''' see [[Aromatase]].<br /> | * '''P450 19 family''' see [[Aromatase]].<br /> | ||
* '''P450 17A1''' see [[Abiraterone acetate|Human steroidogenic cytochrome P450 17A1 with inhibitor abiraterone]] | |||
See also [[Hemeproteins]]. | See also [[Hemeproteins]]. | ||
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*[[Montelukast]] - anti rhinitis | *[[Montelukast]] - anti rhinitis | ||
*[[Noxafil]] - antifungal drug which binds to CYP51. | *[[Noxafil]] - antifungal drug which binds to CYP51. | ||
*[[Antifungal drugs]] - antifungal drugs which binds to CYP51. | |||
*[[Cobicistat]] - anti HIV/AIDS drug which binds to CYP3A4. | |||
*[[Cytochrome P450 inhibitors]] | |||
== Structural highlights == | == Structural highlights == | ||
