8fkm: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8fkm is ~~ON HOLD~~

==Human Atg3 with deletions of residues 1 to 25 and 90 to 190==

~~Authors~~: Ye, Y.S., ~~Tian~~, F.

== Structural highlights ==

<table><tr><td colspan='2'>[[8fkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FKM FirstGlance]. <br>

~~Description~~: ~~Human Atg3 with deletions~~ of ~~residues 90~~ to ~~190~~ and ~~H240Y~~, ~~V241A~~, ~~P263G, and H266L mutations~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fkm OCA], [https://pdbe.org/8fkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fkm RCSB], [https://www.ebi.ac.uk/pdbsum/8fkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fkm ProSAT]</span></td></tr>

[[Category: ~~Ye, Y.S~~]]

</table>

[[Category: Tian, F]]

== Function ==

[https://www.uniprot.org/uniprot/ATG3_HUMAN ATG3_HUMAN] E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.<ref>PMID:11825910</ref> <ref>PMID:12207896</ref> <ref>PMID:12890687</ref> <ref>PMID:16704426</ref> <ref>PMID:20723759</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Tian F]]

[[Category: Ye YS]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8fkm is ON HOLD
+==Human Atg3 with deletions of residues 1 to 25 and 90 to 190==
+<StructureSection load='8fkm' size='340' side='right'caption='[[8fkm]]' scene=''>
-Authors: Ye, Y.S., Tian, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8fkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FKM FirstGlance]. <br>
-Description: Human Atg3 with deletions of residues 90 to 190 and H240Y, V241A, P263G, and H266L mutations
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fkm OCA], [https://pdbe.org/8fkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fkm RCSB], [https://www.ebi.ac.uk/pdbsum/8fkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fkm ProSAT]</span></td></tr>
-[[Category: Ye, Y.S]]
+</table>
-[[Category: Tian, F]]
+== Function ==
+[https://www.uniprot.org/uniprot/ATG3_HUMAN ATG3_HUMAN] E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.<ref>PMID:11825910</ref> <ref>PMID:12207896</ref> <ref>PMID:12890687</ref> <ref>PMID:16704426</ref> <ref>PMID:20723759</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Tian F]]
+[[Category: Ye YS]]