8hut: Difference between revisions
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New page: '''Unreleased structure''' The entry 8hut is ON HOLD Authors: Lin, C., Zhang, J., Li, J. Description: Crystal structure of MERS main protease in complex with S217622 [[Category: Unrele... |
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==Crystal structure of MERS main protease in complex with S217622== | |||
<StructureSection load='8hut' size='340' side='right'caption='[[8hut]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8hut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YY:6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione'>7YY</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hut OCA], [https://pdbe.org/8hut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hut RCSB], [https://www.ebi.ac.uk/pdbsum/8hut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hut ProSAT]</span></td></tr> | ||
[[Category: Li | </table> | ||
[[Category: Zhang | == Function == | ||
[https://www.uniprot.org/uniprot/T2B9I2_MERS T2B9I2_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Middle East respiratory syndrome-related coronavirus]] | |||
[[Category: Li J]] | |||
[[Category: Lin C]] | |||
[[Category: Zhang J]] | |||
Latest revision as of 08:22, 7 February 2024
Crystal structure of MERS main protease in complex with S217622
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