7qqe: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[7qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QQE OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7QQE FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qqe OCA], [https://pdbe.org/7qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qqe RCSB], [https://www.ebi.ac.uk/pdbsum/7qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qqe ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] ~~19p13.3 microduplication~~ syndrome;Malan overgrowth syndrome;~~Marshall-Smith~~ syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Marshall-Smith syndrome;Malan overgrowth syndrome;19p13.3 microduplication syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

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@@ Line 4: / Line 4: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[7qqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QQE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qqe OCA], [https://pdbe.org/7qqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qqe RCSB], [https://www.ebi.ac.uk/pdbsum/7qqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qqe ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] 19p13.3 microduplication syndrome;Malan overgrowth syndrome;Marshall-Smith syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Marshall-Smith syndrome;Malan overgrowth syndrome;19p13.3 microduplication syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
 == Function ==
 [https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.