Pyruvate carboxylase: Difference between revisions

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==Function==

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==Disease==

Mutations in the PC gene cause 3 types of clinical spectra. Type A and B are neonatal forms causing early death; type C causes mild intellectual delay<ref>PMID:30870574</ref> . Deregulation of PC expression is associated with type 2 diabetics and tumorgenesis in several cancers<ref>PMID:29362846</ref> .

Mutations in the PC gene cause 3 types of clinical spectra. Type A and B are neonatal forms causing early death; type C causes mild intellectual delay<ref>PMID:30870574</ref>. Deregulation of PC expression is associated with type 2 diabetics and tumorgenesis in several cancers<ref>PMID:29362846</ref> .

==Structural highlights==

The 3D structure of PC shows its 4 domains: BC, CT, allosteric effector and BCCP. The ATP moiety active site is in the BC domain and contains 2 Mg++ ions. The effector CoA is bound to the BC domain and the allosteric effector domain<ref>PMID:17717183</ref> .

The 3D structure of PC shows its <scene name='93/939263/Cv/3'>4 domains: BC, CT, allosteric effector and BCCP</scene>.

The <scene name='93/939263/Cv/7'>ATP moiety active site is in the BC domain and contains 2 Mg++ ions</scene>. Water molecules shown as red spheres. <scene name='93/939263/Cv/8'>Close up view of 2 Mg++ coordination sites</scene>.

The <scene name='93/939263/Cv/9'>effector CoA is bound to the BC domain and the allosteric effector domain</scene><ref>PMID:17717183</ref>.

==3D structures of pyruvate carboxylase==

Pyruvate carboxylase: Difference between revisions

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@@ Line 1: / Line 1: @@
-<StructureSection load='2qf7' size='340' side='right' caption='Pyruvate carboxylase complex with CoA, ATP-gamma-S,glycerol, Mg++ (green), Zn++ (grey) Cl- (green) (PDB code [[2qf7]])' scene=''>
+<StructureSection load='2qf7' size='340' side='right' caption='Pyruvate carboxylase complex with CoA, ATP-gamma-S, glycerol, Mg++ (green), Zn++ (grey) Cl- (green) (PDB code [[2qf7]])' scene='93/939263/Cv/2'>
 ==Function==
@@ Line 9: / Line 9: @@
 ==Disease==
-Mutations in the PC gene cause 3 types of clinical spectra.  Type A and B are neonatal forms causing early death; type C causes mild intellectual delay<ref>PMID:30870574</ref> .  Deregulation of PC expression is associated with type 2 diabetics and tumorgenesis in several cancers<ref>PMID:29362846</ref> .
+Mutations in the PC gene cause 3 types of clinical spectra.  Type A and B are neonatal forms causing early death; type C causes mild intellectual delay<ref>PMID:30870574</ref>. Deregulation of PC expression is associated with type 2 diabetics and tumorgenesis in several cancers<ref>PMID:29362846</ref> .
 ==Structural highlights==
-The 3D structure of PC shows its 4 domains: BC, CT, allosteric effector and BCCP.  The ATP moiety active site is in the BC domain and contains 2 Mg++ ions.  The effector CoA is bound to the BC domain and the allosteric effector domain<ref>PMID:17717183</ref> .
+The 3D structure of PC shows its <scene name='93/939263/Cv/3'>4 domains: BC, CT, allosteric effector and BCCP</scene>.
+The <scene name='93/939263/Cv/7'>ATP moiety active site is in the BC domain and contains 2 Mg++ ions</scene>. Water molecules shown as red spheres. <scene name='93/939263/Cv/8'>Close up view of 2 Mg++ coordination sites</scene>.
+The <scene name='93/939263/Cv/9'>effector CoA is bound to the BC domain and the allosteric effector domain</scene><ref>PMID:17717183</ref>.
 ==3D structures of pyruvate carboxylase==