8c9e: Difference between revisions
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==Priestia megaterium mupirocin-sensitive isoleucyl-tRNA synthetase 1 complexed with an isoleucyl-adenylate analogue== | |||
<StructureSection load='8c9e' size='340' side='right'caption='[[8c9e]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C9E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ILA:N-[ISOLEUCINYL]-N-[ADENOSYL]-DIAMINOSUFONE'>ILA</scene>, <scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c9e OCA], [https://pdbe.org/8c9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c9e RCSB], [https://www.ebi.ac.uk/pdbsum/8c9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c9e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0B6A6A8_PRIM2 A0A0B6A6A8_PRIM2] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).[ARBA:ARBA00025217][HAMAP-Rule:MF_02002] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Priestia megaterium]] | |||
[[Category: Ban N]] | |||
[[Category: Brkic A]] | |||
[[Category: Car Z]] | |||
[[Category: Gruic-Sovulj I]] | |||
[[Category: Jablonska J]] | |||
[[Category: Leibundgut M]] | |||
[[Category: Petrovic Perokovic V]] | |||
[[Category: Zanki V]] | |||
Latest revision as of 08:21, 16 August 2023
Priestia megaterium mupirocin-sensitive isoleucyl-tRNA synthetase 1 complexed with an isoleucyl-adenylate analogue
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