8ccq: Difference between revisions

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New page: '''Unreleased structure''' The entry 8ccq is ON HOLD Authors: Engrola, F., Santos-Silva, T., Romao, M.J., Correia, M.A.S. Description: Crystal structure of arsenite oxidase from Pseudo...
 
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'''Unreleased structure'''


The entry 8ccq is ON HOLD
==Crystal structure of arsenite oxidase from Pseudorhizobium banfieldiae str. NT-26 (NT-26 Aio) bound to antimony trioxide==
<StructureSection load='8ccq' size='340' side='right'caption='[[8ccq]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ccq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudorhizobium_banfieldiae Pseudorhizobium banfieldiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CCQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MO:MOLYBDENUM(IV)+ION'>4MO</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MGD:2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE+GUANOSINE+DINUCLEOTIDE'>MGD</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SBO:TRIHYDROXYANTIMONITE(III)'>SBO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ccq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ccq OCA], [https://pdbe.org/8ccq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ccq RCSB], [https://www.ebi.ac.uk/pdbsum/8ccq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ccq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6VAL8_9HYPH Q6VAL8_9HYPH]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Arsenic contamination of groundwater is among one of the biggest health threats affecting millions of people in the world. There is an urgent need for efficient arsenic biosensors where the use of arsenic metabolizing enzymes can be explored. In this work, we have solved four crystal structures of arsenite oxidase (Aio) in complex with arsenic and antimony oxyanions and the structures determined correspond to intermediate states of the enzymatic mechanism. These structural data were complemented with density-functional theory calculations providing a unique view of the molybdenum active site at different time points that, together with mutagenesis data, enabled to clarify the enzymatic mechanism and the molecular determinants for the oxidation of As(III) to the less toxic As(V) species.


Authors: Engrola, F., Santos-Silva, T., Romao, M.J., Correia, M.A.S.
Arsenite oxidase in complex with antimonite and arsenite oxyanions: Insights into the catalytic mechanism.,Engrola F, Correia MAS, Watson C, Romao CC, Veiros LF, Romao MJ, Santos-Silva T, Santini JM J Biol Chem. 2023 Aug;299(8):105036. doi: 10.1016/j.jbc.2023.105036. Epub 2023 , Jul 11. PMID:37442232<ref>PMID:37442232</ref>


Description: Crystal structure of arsenite oxidase from Pseudorhizobium banfieldiae str. NT-26 (NT-26 Aio) bound to antimony trioxide
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Engrola, F]]
<div class="pdbe-citations 8ccq" style="background-color:#fffaf0;"></div>
[[Category: Correia, M.A.S]]
== References ==
[[Category: Santos-Silva, T]]
<references/>
[[Category: Romao, M.J]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudorhizobium banfieldiae]]
[[Category: Correia MAS]]
[[Category: Engrola F]]
[[Category: Romao MJ]]
[[Category: Santos-Silva T]]
Retrieved from "https://proteopedia.org/8ccq"