8hut: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8hut is ~~ON HOLD until 2024~~-12-24

==Crystal structure of MERS main protease in complex with S217622==

~~Authors~~: ~~Lin~~, C., ~~Zhang~~, J., Li, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[8hut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUT OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8HUT FirstGlance].

~~Description~~: ~~Crystal~~ structure ~~of MERS main protease in complex with S217622~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YY:6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione'>7YY</scene></td></tr>

[[Category: ~~Lin, C~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8hut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hut OCA], [https://pdbe.org/8hut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hut RCSB], [https://www.ebi.ac.uk/pdbsum/8hut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hut ProSAT]</td></tr>

[[Category: Li, J]]

</table>

[[Category: Zhang, J]]

== Function ==

[https://www.uniprot.org/uniprot/T2B9I2_MERS T2B9I2_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Middle East respiratory syndrome-related coronavirus]]

[[Category: Li J]]

[[Category: Lin C]]

[[Category: Zhang J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8hut is ON HOLD  until 2024-12-24
+==Crystal structure of MERS main protease in complex with S217622==
+<StructureSection load='8hut' size='340' side='right'caption='[[8hut]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
-Authors: Lin, C., Zhang, J., Li, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hut]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUT FirstGlance]. <br>
-Description: Crystal structure of MERS main protease in complex with S217622
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7YY:6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione'>7YY</scene></td></tr>
-[[Category: Lin, C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hut OCA], [https://pdbe.org/8hut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hut RCSB], [https://www.ebi.ac.uk/pdbsum/8hut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hut ProSAT]</span></td></tr>
-[[Category: Li, J]]
+</table>
-[[Category: Zhang, J]]
+== Function ==
+[https://www.uniprot.org/uniprot/T2B9I2_MERS T2B9I2_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Middle East respiratory syndrome-related coronavirus]]
+[[Category: Li J]]
+[[Category: Lin C]]
+[[Category: Zhang J]]