8i9i: Difference between revisions

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New page: '''Unreleased structure''' The entry 8i9i is ON HOLD Authors: Dev, A., Chongdar, N., Dasgupta, S., Basu, G. Description: Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutama...
 
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'''Unreleased structure'''


The entry 8i9i is ON HOLD
==Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutamate and Zinc==
 
<StructureSection load='8i9i' size='340' side='right'caption='[[8i9i]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: Dev, A., Chongdar, N., Dasgupta, S., Basu, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8i9i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I9I FirstGlance]. <br>
Description: Glutamyl-tRNA synthetase from Escherichia Coli bound to Glutamate and Zinc
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Basu, G]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i9i OCA], [https://pdbe.org/8i9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i9i RCSB], [https://www.ebi.ac.uk/pdbsum/8i9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i9i ProSAT]</span></td></tr>
[[Category: Chongdar, N]]
</table>
[[Category: Dev, A]]
== Function ==
[[Category: Dasgupta, S]]
[https://www.uniprot.org/uniprot/SYE_ECOLI SYE_ECOLI] Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).<ref>PMID:14764088</ref> <ref>PMID:6280993</ref> <ref>PMID:6986385</ref> <ref>PMID:7797500</ref> <ref>PMID:8218204</ref>  Phosphorylation of GltX by HipA prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence (PubMed:24095282, PubMed:24343429). Overexpression of GltX prevents HipA-induced growth arrest, persister formation and increases in (p)ppGpp levels (PubMed:24343429, PubMed:28430938).<ref>PMID:24095282</ref> <ref>PMID:24343429</ref> <ref>PMID:28430938</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Basu G]]
[[Category: Chongdar N]]
[[Category: Dasgupta S]]
[[Category: Dev A]]
Retrieved from "https://proteopedia.org/8i9i"