8g65: Difference between revisions
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==Wildtype PTP1b in complex with DES4799== | |||
<StructureSection load='8g65' size='340' side='right'caption='[[8g65]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8g65]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G65 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YW9:4-(3,5-dimethyl-1H-pyrazol-1-yl)aniline'>YW9</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g65 OCA], [https://pdbe.org/8g65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g65 RCSB], [https://www.ebi.ac.uk/pdbsum/8g65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g65 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
==See Also== | |||
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Giordanetto F]] | |||
[[Category: Greisman JB]] | |||
[[Category: Maragakis P]] | |||
[[Category: Nisonoff H]] | |||
[[Category: Shahamadtar S]] | |||
[[Category: Shaw DE]] | |||
[[Category: Willmore L]] | |||
[[Category: Yeh CY]] | |||
Latest revision as of 10:49, 22 May 2024
Wildtype PTP1b in complex with DES4799
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