Netropsin: Difference between revisions
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<StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'> | <StructureSection load='101d' size='350' side='right' caption='NETROPSIN BOUND TO DNA' scene='95/953835/Cv/1'> | ||
Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. | Netropsin (also termed congocidine or sinanomycin) is a polyamide with antibiotic and antiviral activity. It belongs to the class of pyrrole-amidine antibiotics. See also [https://en.wikipedia.org/wiki/Netropsin]. | ||
Netropsin binds to the minor groove of AT-rich sequences of double stranded DNA. In contrast, netropsin does not bind single stranded DNA or double stranded RNA. Crystallographic structures of DNA-bound Netropsin have been obtained and elucidate details of how the drug binds in the minor groove. <scene name='95/953835/Cv/3'>In the bound structure, the drug makes hydrogen bonding interactions with several subsequent base pairs of the DNA duplex</scene>, locally displacing the water molecules of the spine of hydration. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 15:54, 22 February 2023
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