1iu1: Difference between revisions
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New page: left|200px<br /> <applet load="1iu1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iu1, resolution 1.80Å" /> '''Crystal structure o... |
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== | ==Crystal structure of human gamma1-adaptin ear domain== | ||
The adaptor proteins AP-1 and GGA regulate membrane traffic between the | <StructureSection load='1iu1' size='340' side='right'caption='[[1iu1]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1iu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IU1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu1 OCA], [https://pdbe.org/1iu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iu1 RCSB], [https://www.ebi.ac.uk/pdbsum/1iu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iu1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AP1G1_HUMAN AP1G1_HUMAN] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/1iu1_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iu1 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The adaptor proteins AP-1 and GGA regulate membrane traffic between the trans-Golgi network (TGN) and endosomes/lysosomes through ARF-regulated membrane association, recognition of sorting signals, and recruitment of clathrin and accessory proteins. The gamma 1-adaptin subunits of AP-1 and GGA possess homologous ear domains involved in the recruitment of accessory proteins, gamma-synergin and Rabaptin-5. The crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain. Structure-based mutational analyses reveal a binding site for the accessory proteins that is composed of conserved basic residues, indicating that the recruitment mechanism in gamma 1-adaptin and GGA is distinct from that in alpha-adaptin. | |||
Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.,Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:12042876<ref>PMID:12042876</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1iu1" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Adaptin 3D structures|Adaptin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Igarashi | [[Category: Igarashi N]] | ||
[[Category: Kato | [[Category: Kato R]] | ||
[[Category: Kawasaki | [[Category: Kawasaki M]] | ||
[[Category: Matsugaki | [[Category: Matsugaki N]] | ||
[[Category: Nakayama | [[Category: Nakayama K]] | ||
[[Category: Nogi | [[Category: Nogi T]] | ||
[[Category: Shiba | [[Category: Shiba T]] | ||
[[Category: Shiba | [[Category: Shiba Y]] | ||
[[Category: Suzuki | [[Category: Suzuki M]] | ||
[[Category: Takatsu | [[Category: Takatsu H]] | ||
[[Category: Wakatsuki | [[Category: Wakatsuki S]] | ||
Latest revision as of 23:36, 27 December 2023
Crystal structure of human gamma1-adaptin ear domain
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