1k2k: Difference between revisions
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==NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2== | |||
<StructureSection load='1k2k' size='340' side='right'caption='[[1k2k]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1k2k]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K2K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2k OCA], [https://pdbe.org/1k2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k2k RCSB], [https://www.ebi.ac.uk/pdbsum/1k2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k2k ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
''' | == Publication Abstract from PubMed == | ||
== | |||
Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed. | Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed. | ||
Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2).,Lam SL, Ip LN J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844<ref>PMID:11922844</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1k2k" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ip LN]] | |||
[[Category: Lam SL]] | |||
Latest revision as of 18:45, 29 November 2023
NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2
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