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[[Image:1k6u.jpg|left|200px]]
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{{STRUCTURE_1k6u|  PDB=1k6u  |  SCENE=  }}
'''Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor'''


==Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor==
<StructureSection load='1k6u' size='340' side='right'caption='[[1k6u]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1k6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6u OCA], [https://pdbe.org/1k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6u RCSB], [https://www.ebi.ac.uk/pdbsum/1k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6u ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a cyclic form of a mutant of bovine pancreatic trypsin inhibitor has been solved at 1.0 A resolution. The protein was synthesized by native chemical ligation and its structure is almost indistinguishable from the previously described recombinant form of the same mutant; however, the new loop containing the former termini became much better ordered.


==Overview==
Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.,Botos I, Wu Z, Lu W, Wlodawer A FEBS Lett. 2001 Nov 30;509(1):90-4. PMID:11734212<ref>PMID:11734212</ref>
The crystal structure of a cyclic form of a mutant of bovine pancreatic trypsin inhibitor has been solved at 1.0 A resolution. The protein was synthesized by native chemical ligation and its structure is almost indistinguishable from the previously described recombinant form of the same mutant; however, the new loop containing the former termini became much better ordered.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1K6U is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6U OCA].
</div>
<div class="pdbe-citations 1k6u" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor., Botos I, Wu Z, Lu W, Wlodawer A, FEBS Lett. 2001 Nov 30;509(1):90-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11734212 11734212]
*[[BPTI 3D structures|BPTI 3D structures]]
[[Category: Single protein]]
== References ==
[[Category: Botos, I.]]
<references/>
[[Category: Lu, W.]]
__TOC__
[[Category: Wlodawer, A.]]
</StructureSection>
[[Category: Wu, Z.]]
[[Category: Bos taurus]]
[[Category: Atomic resolution]]
[[Category: Large Structures]]
[[Category: Bpti]]
[[Category: Botos I]]
[[Category: Cyclic protein]]
[[Category: Lu W]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:22:47 2008''
[[Category: Wlodawer A]]
[[Category: Wu Z]]

Latest revision as of 06:53, 30 October 2024

Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor

1k6u, resolution 1.00Å

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