1jh5: Difference between revisions

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New page: left|200px<br /> <applet load="1jh5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jh5, resolution 3.00Å" /> '''Crystal Structure o...
 
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[[Image:1jh5.gif|left|200px]]<br />
<applet load="1jh5" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jh5, resolution 3.00&Aring;" />
'''Crystal Structure of sTALL-1 of TNF family ligand'''<br />


==Overview==
==Crystal Structure of sTALL-1 of TNF family ligand==
TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis, factor (TNF) ligand family. The crystal structure of the functional, soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a, virus-like assembly with 200 A diameter in the crystals, containing 60, sTALL-1 monomers. The cluster formation is mediated by a "flap" region of, the sTALL-1 monomer. The virus-like assembly was also detected in solution, using gel filtration and electron microscopy. Deletion of the flap region, disrupted the formation of the virus-like assembly. The mutant sTALL-1, still bound its receptor but could not activate NF-kappaB and did not, stimulate B lymphocyte proliferation. Finally, we found the virus-like, cluster of sTALL-1 exists in physiological condition. We propose that this, virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.
<StructureSection load='1jh5' size='340' side='right'caption='[[1jh5]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jh5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JH5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jh5 OCA], [https://pdbe.org/1jh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jh5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jh5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>  Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jh5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jh5 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1JH5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JH5 OCA].
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
 
== References ==
==Reference==
<references/>
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11853672 11853672]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Opalka, N.]]
[[Category: Opalka N]]
[[Category: Shu, H.B.]]
[[Category: Shu H-B]]
[[Category: Xu, L.]]
[[Category: Xu L]]
[[Category: Zhang, G.]]
[[Category: Zhang G]]
[[Category: baff]]
[[Category: blys]]
[[Category: tall-1]]
[[Category: thank]]
 
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