8cnb: Difference between revisions
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==Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A== | |||
<StructureSection load='8cnb' size='340' side='right'caption='[[8cnb]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8cnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CNB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.986Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cnb OCA], [https://pdbe.org/8cnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cnb RCSB], [https://www.ebi.ac.uk/pdbsum/8cnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cnb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Green M]] | |||
[[Category: Haouz A]] | |||
[[Category: Mechaly AE]] | |||
[[Category: Rodrigues-Lima F]] | |||
[[Category: Zhang W]] | |||
Latest revision as of 14:26, 6 November 2024
Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
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