1w33: Difference between revisions
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New page: left|200px<br /> <applet load="1w33" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w33, resolution 2.7Å" /> '''BBCRASP-1 FROM BORRE... |
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== | ==BbCRASP-1 from Borrelia Burgdorferi== | ||
Borrelia burgdorferi, a spirochete transmitted to human hosts during | <StructureSection load='1w33' size='340' side='right'caption='[[1w33]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1w33]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_ZS7 Borreliella burgdorferi ZS7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W33 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w33 OCA], [https://pdbe.org/1w33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w33 RCSB], [https://www.ebi.ac.uk/pdbsum/1w33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w33 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/O50957_BORBU O50957_BORBU] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w33_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w33 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design. | |||
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.,Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564<ref>PMID:15711564</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1w33" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Complement Regulator-Acquiring Surface Protein|Complement Regulator-Acquiring Surface Protein]] | |||
*[[Complement regulator-acquiring surface protein|Complement regulator-acquiring surface protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Borreliella burgdorferi ZS7]] | |||
[[Category: Large Structures]] | |||
[[Category: Brade V]] | |||
[[Category: Cordes FS]] | |||
[[Category: Goodstadt L]] | |||
[[Category: Kirschfink M]] | |||
[[Category: Kraiczy P]] | |||
[[Category: Lea SM]] | |||
[[Category: Ponting C]] | |||
[[Category: Roversi P]] | |||
[[Category: Simon MM]] | |||
[[Category: Skerka C]] | |||
[[Category: Wallich R]] | |||
[[Category: Zipfel P]] | |||
Latest revision as of 09:09, 9 May 2024
BbCRASP-1 from Borrelia Burgdorferi
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