8j0k: Difference between revisions
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==Crystal structure of human TFAP2A in complex with DNA== | |||
<StructureSection load='8j0k' size='340' side='right'caption='[[8j0k]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8j0k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J0K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG3:GUANIDINE-3-PROPANOL'>PG3</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j0k OCA], [https://pdbe.org/8j0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j0k RCSB], [https://www.ebi.ac.uk/pdbsum/8j0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j0k ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Li | == Disease == | ||
[[Category: Liu | [https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Branchio-oculo-facial syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AP2A_HUMAN AP2A_HUMAN] Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.<ref>PMID:11694877</ref> <ref>PMID:12586840</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Li WF]] | |||
[[Category: Liu K]] | |||
[[Category: Min JR]] | |||
[[Category: Xiao YQ]] | |||
Latest revision as of 05:46, 5 July 2023
Crystal structure of human TFAP2A in complex with DNA
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