Sandbox Reserved 1790: Difference between revisions

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===SHOC2 and PP1C interactions===

<scene name='95/952717/Shoc2_and_pp1c/1'>PP1C binds to SHOC2</scene> on its leucine rich region(LRR). Between LRR2 and LRR5 and between LRR7 and LRR11. Mutations between SHOC2 and PP1C to the LRR were shown to completely inhibit the binding of PP1C. Five main <scene name='95/952716/Shoc2_and_pp1c/3'>hydrogen and ionic bonds</scene> are made between PP1C and SHOC2 respectively: E56-R182, E167-R203, E54-K180, R187-H178, R188-E155 <ref name="Kwon">PMID:35831509</ref>. Reflecting this ionic character, the binding regions are contained within extensive acidic and basic patches on <scene name='95/952718/Acid_base_pp1c/1'>PP1C</scene> and <scene name='95/952718/Acid_base_shoc2/2'>SHOC2</scene>. The negative acidic patches of PP1C interact with the positive basic patches of SHOC2 and vice versa to form a <scene name='95/952718/Acid_base_shoc2pp1c/1'>binary complex</scene>. These interactions do not result in significant conformational changes to PP1C in comparison to other protein interactions that can be made with PP1C <ref name="Kwon">PMID:35831509</ref>.

<scene name='95/952717/Shoc2_and_pp1c/1'>PP1C binds to SHOC2</scene> on its leucine rich region(LRR). Between LRR2 and LRR5 and between LRR7 and LRR11. Mutations between SHOC2 and PP1C to the LRR were shown to completely inhibit the binding of PP1C. Five main <scene name='95/952716/Shoc2_and_pp1c/3'>hydrogen and ionic bonds</scene> are made between PP1C and SHOC2 respectively: E56-R182, E167-R203, E54-K180, R187-H178, R188-E155 <ref name="Kwon">PMID:35831509</ref>. Reflecting this ionic character, the binding regions are contained within extensive acidic and basic patches on <scene name='95/952718/Acid_base_pp1c/2'>PP1C</scene> and <scene name='95/952718/Acid_base_shoc2/2'>SHOC2</scene>. The negative acidic patches of PP1C interact with the positive basic patches of SHOC2 and vice versa to form a <scene name='95/952718/Acid_base_shoc2pp1c/1'>binary complex</scene>. These interactions do not result in significant conformational changes to PP1C in comparison to other protein interactions that can be made with PP1C <ref name="Kwon">PMID:35831509</ref>.

==MRAS==

Sandbox Reserved 1790: Difference between revisions

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 ===SHOC2 and PP1C interactions===
-<scene name='95/952717/Shoc2_and_pp1c/1'>PP1C binds to SHOC2</scene> on its leucine rich region(LRR). Between LRR2 and LRR5 and between LRR7 and LRR11. Mutations between SHOC2 and PP1C to the LRR were shown to completely inhibit the binding of PP1C. Five main <scene name='95/952716/Shoc2_and_pp1c/3'>hydrogen and ionic bonds</scene> are made between PP1C and SHOC2 respectively: E56-R182, E167-R203, E54-K180, R187-H178, R188-E155 <ref name="Kwon">PMID:35831509</ref>. Reflecting this ionic character, the binding regions are contained within extensive acidic and basic patches on <scene name='95/952718/Acid_base_pp1c/1'>PP1C</scene> and <scene name='95/952718/Acid_base_shoc2/2'>SHOC2</scene>. The negative acidic patches of PP1C interact with the positive basic patches of SHOC2 and vice versa to form a <scene name='95/952718/Acid_base_shoc2pp1c/1'>binary complex</scene>. These interactions do not result in significant conformational changes to PP1C in comparison to other protein interactions that can be made with PP1C <ref name="Kwon">PMID:35831509</ref>.
+<scene name='95/952717/Shoc2_and_pp1c/1'>PP1C binds to SHOC2</scene> on its leucine rich region(LRR). Between LRR2 and LRR5 and between LRR7 and LRR11. Mutations between SHOC2 and PP1C to the LRR were shown to completely inhibit the binding of PP1C. Five main <scene name='95/952716/Shoc2_and_pp1c/3'>hydrogen and ionic bonds</scene> are made between PP1C and SHOC2 respectively: E56-R182, E167-R203, E54-K180, R187-H178, R188-E155 <ref name="Kwon">PMID:35831509</ref>. Reflecting this ionic character, the binding regions are contained within extensive acidic and basic patches on <scene name='95/952718/Acid_base_pp1c/2'>PP1C</scene> and <scene name='95/952718/Acid_base_shoc2/2'>SHOC2</scene>. The negative acidic patches of PP1C interact with the positive basic patches of SHOC2 and vice versa to form a <scene name='95/952718/Acid_base_shoc2pp1c/1'>binary complex</scene>. These interactions do not result in significant conformational changes to PP1C in comparison to other protein interactions that can be made with PP1C <ref name="Kwon">PMID:35831509</ref>.
 ==MRAS==