7fx0: Difference between revisions

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'''Unreleased structure'''


The entry 7fx0 is ON HOLD
==Crystal Structure of human FABP4 in complex with 5-[(2-chloroanilino)methyl]-4-ethyl-1,2,4-triazole-3-thiol, i.e. SMILES N1(C(=NN=C1CNc1c(Cl)cccc1)S)CC with IC50=0.705 microM==
 
<StructureSection load='7fx0' size='340' side='right'caption='[[7fx0]], [[Resolution|resolution]] 1.03&Aring;' scene=''>
Authors: Ehler, A., Benz, J., Obst, U., Brunner, M., Rudolph, M.G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7fx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FX0 FirstGlance]. <br>
Description: Crystal Structure of human FABP4 in complex with 5-[(2-chloroanilino)methyl]-4-ethyl-1,2,4-triazole-3-thiol
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.03&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=QG0:5-[(2-chloroanilino)methyl]-4-ethyl-4H-1,2,4-triazole-3-thiol'>QG0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Ehler, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fx0 OCA], [https://pdbe.org/7fx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fx0 RCSB], [https://www.ebi.ac.uk/pdbsum/7fx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fx0 ProSAT]</span></td></tr>
[[Category: Benz, J]]
</table>
[[Category: Obst, U]]
== Function ==
[[Category: Brunner, M]]
[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
[[Category: Rudolph, M.G]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Benz J]]
[[Category: Brunner M]]
[[Category: Ehler A]]
[[Category: Obst U]]
[[Category: Rudolph MG]]
Retrieved from "https://proteopedia.org/7fx0"