7fxd: Difference between revisions
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New page: '''Unreleased structure''' The entry 7fxd is ON HOLD Authors: Ehler, A., Benz, J., Obst, U., Ning, R., Rudolph, M.G. Description: Crystal Structure of human FABP5 in complex with 2-(in... |
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==Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e. SMILES c12N(C(=O)Nc3c(cccc3)C(=O)O)C=Cc1cccc2 with IC50=18.1696 microM== | |||
<StructureSection load='7fxd' size='340' side='right'caption='[[7fxd]], [[Resolution|resolution]] 2.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7fxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FXD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NC0:2-[(2,3-dihydro-1H-indole-1-carbonyl)amino]benzoic+acid'>NC0</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fxd OCA], [https://pdbe.org/7fxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fxd RCSB], [https://www.ebi.ac.uk/pdbsum/7fxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fxd ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: Obst | [https://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation. | ||
[[Category: Rudolph | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Benz J]] | |||
[[Category: Ehler A]] | |||
[[Category: Ning R]] | |||
[[Category: Obst U]] | |||
[[Category: Rudolph MG]] | |||
Latest revision as of 08:33, 13 August 2025
Crystal Structure of human FABP5 in complex with 2-(indole-1-carbonylamino)benzoic acid, i.e. SMILES c12N(C(=O)Nc3c(cccc3)C(=O)O)C=Cc1cccc2 with IC50=18.1696 microM
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