7fyv: Difference between revisions

(2 intermediate revisions by the same user not shown)

Line 1:

~~'''Unreleased structure'''~~

~~The entry 7fyv is ON HOLD~~

==Crystal Structure of human FABP4 in complex with 5-(4-chlorophenyl)-9-methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene-8-carboxylic acid, i.e. SMILES [C@H]12[C@H]3[C@@H]([C@@H]([C@@H]([C@H]1ON=C2c1ccc(cc1)Cl)C3)C)C(=O)O with IC50=5.6 microM==

~~Authors: Ehler, A., Benz, J., Obst, U., Wickens, J., Rudolph, M.G.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[7fyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FYV OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7FYV FirstGlance].

~~Description:~~ Crystal Structure of human FABP4 in complex with 5-(4-chlorophenyl)-9-methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene-8-carboxylic acid

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W9Q:(3aR,4R,5R,6S,7R,7aR)-3-(4-chlorophenyl)-6-methyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzoxazole-5-carboxylic+acid'>W9Q</scene></td></tr>

[[Category: ~~Wickens,~~ J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7fyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fyv OCA], [https://pdbe.org/7fyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fyv RCSB], [https://www.ebi.ac.uk/pdbsum/7fyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fyv ProSAT]</td></tr>

[[Category: Ehler, A]]

</table>

[[Category: ~~Benz, J~~]]

== Function ==

[[Category: ~~Obst, U~~]]

[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

[[Category: ~~Rudolph, M.G~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Benz J]]

[[Category: Ehler A]]

[[Category: Obst U]]

[[Category: Rudolph MG]]

[[Category: Wickens J]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7fyv is ON HOLD
+==Crystal Structure of human FABP4 in complex with 5-(4-chlorophenyl)-9-methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene-8-carboxylic acid, i.e. SMILES [C@H]12[C@H]3[C@@H]([C@@H]([C@@H]([C@H]1ON=C2c1ccc(cc1)Cl)C3)C)C(=O)O with IC50=5.6 microM==
+<StructureSection load='7fyv' size='340' side='right'caption='[[7fyv]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
-Authors: Ehler, A., Benz, J., Obst, U., Wickens, J., Rudolph, M.G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7fyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FYV FirstGlance]. <br>
-Description: Crystal Structure of human FABP4 in complex with 5-(4-chlorophenyl)-9-methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene-8-carboxylic acid
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W9Q:(3aR,4R,5R,6S,7R,7aR)-3-(4-chlorophenyl)-6-methyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzoxazole-5-carboxylic+acid'>W9Q</scene></td></tr>
-[[Category: Wickens, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fyv OCA], [https://pdbe.org/7fyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fyv RCSB], [https://www.ebi.ac.uk/pdbsum/7fyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fyv ProSAT]</span></td></tr>
-[[Category: Ehler, A]]
+</table>
-[[Category: Benz, J]]
+== Function ==
-[[Category: Obst, U]]
+[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
-[[Category: Rudolph, M.G]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Benz J]]
+[[Category: Ehler A]]
+[[Category: Obst U]]
+[[Category: Rudolph MG]]
+[[Category: Wickens J]]