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New page: left|200px<br /> <applet load="1jxv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jxv, resolution 2.2Å" /> '''Crystal Structure of...
 
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[[Image:1jxv.gif|left|200px]]<br />
<applet load="1jxv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1jxv, resolution 2.2&Aring;" />
'''Crystal Structure of Human Nucleoside Diphosphate Kinase A'''<br />


==Disease==
==Crystal Structure of Human Nucleoside Diphosphate Kinase A==
Known disease associated with this structure: Neuroblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=156490 156490]]
<StructureSection load='1jxv' size='340' side='right'caption='[[1jxv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1jxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxv OCA], [https://pdbe.org/1jxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxv RCSB], [https://www.ebi.ac.uk/pdbsum/1jxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NDKA_HUMAN NDKA_HUMAN] Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.<ref>PMID:2056128</ref> <ref>PMID:8810265</ref> <ref>PMID:12628186</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxv ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1JXV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JXV OCA].
*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
 
== References ==
==Reference==
<references/>
Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor., Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW, Proteins. 2002 Feb 15;46(3):340-2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11835509 11835509]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Chang C]]
[[Category: Chang, C.]]
[[Category: Kim SY]]
[[Category: Kim, S.Y.]]
[[Category: Lee KJ]]
[[Category: Lee, K.J.]]
[[Category: Min K]]
[[Category: Min, K.]]
[[Category: Song HK]]
[[Category: Song, H.K.]]
[[Category: Suh SW]]
[[Category: Suh, S.W.]]
[[Category: kinase]]
[[Category: transferase]]
 
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Retrieved from "https://proteopedia.org/1jxv"