8srz: Difference between revisions
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New page: '''Unreleased structure''' The entry 8srz is ON HOLD until Paper Publication Authors: Johnson, A.G., Kranzusch, P.J. Description: Structure of a bacterial death-like domain from Lysoba... |
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==Structure of a bacterial death-like domain from Lysobacter enzymogenes== | |||
<StructureSection load='8srz' size='340' side='right'caption='[[8srz]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8srz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srz OCA], [https://pdbe.org/8srz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srz RCSB], [https://www.ebi.ac.uk/pdbsum/8srz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srz ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Johnson | == Function == | ||
[https://www.uniprot.org/uniprot/PROT2_LYSEN PROT2_LYSEN] Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.<ref>PMID:35025633</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Lysobacter enzymogenes]] | |||
[[Category: Johnson AG]] | |||
[[Category: Kranzusch PJ]] | |||
Latest revision as of 06:24, 19 July 2023
Structure of a bacterial death-like domain from Lysobacter enzymogenes
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