8p2p: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 8p2p is ON HOLD Authors: Coste, F., Mance, L., Pukalo, Z., Suskiewicz, M.J. Description: Polymeric form of the BTB domain of human ZBTB18 [[Categor... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Polymeric form of the BTB domain of human ZBTB18== | |||
<StructureSection load='8p2p' size='340' side='right'caption='[[8p2p]], [[Resolution|resolution]] 4.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8p2p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P2P FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.15Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p2p OCA], [https://pdbe.org/8p2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p2p RCSB], [https://www.ebi.ac.uk/pdbsum/8p2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p2p ProSAT]</span></td></tr> | ||
[[Category: Coste | </table> | ||
[[Category: | == Disease == | ||
[[Category: Pukalo | [https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Distal deletion 1q. The disease is caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.<ref>PMID:9756912</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Coste F]] | |||
[[Category: Mance L]] | |||
[[Category: Pukalo Z]] | |||
[[Category: Suskiewicz MJ]] | |||
Latest revision as of 05:17, 5 June 2024
Polymeric form of the BTB domain of human ZBTB18
| ||||||||||||
