8p5j: Difference between revisions

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New page: '''Unreleased structure''' The entry 8p5j is ON HOLD until Paper Publication Authors: Battista, T., Semrau, M.S., Heroux, A., Lolli, G., Storici, P. Description: Kinase domain of mutan...
 
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'''Unreleased structure'''


The entry 8p5j is ON HOLD  until Paper Publication
==Kinase domain of mutant human ULK1 in complex with compound WZ4003==
 
<StructureSection load='8p5j' size='340' side='right'caption='[[8p5j]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
Authors: Battista, T., Semrau, M.S., Heroux, A., Lolli, G., Storici, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8p5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P5J FirstGlance]. <br>
Description: Kinase domain of mutant human ULK1 in complex with compound WZ4003
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.164&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WYT:~{N}-[3-[5-chloranyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]oxyphenyl]propanamide'>WYT</scene></td></tr>
[[Category: Storici, P]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p5j OCA], [https://pdbe.org/8p5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p5j RCSB], [https://www.ebi.ac.uk/pdbsum/8p5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p5j ProSAT]</span></td></tr>
[[Category: Lolli, G]]
</table>
[[Category: Semrau, M.S]]
== Function ==
[[Category: Battista, T]]
[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref>
[[Category: Heroux, A]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Battista T]]
[[Category: Heroux A]]
[[Category: Lolli G]]
[[Category: Semrau MS]]
[[Category: Storici P]]
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