8t49: Difference between revisions
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New page: '''Unreleased structure''' The entry 8t49 is ON HOLD Authors: Ozorowski, G., Torres, J.L., Ward, A.B. Description: MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab [[C... |
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==MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab== | |||
<StructureSection load='8t49' size='340' side='right'caption='[[8t49]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8t49]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T49 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t49 OCA], [https://pdbe.org/8t49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t49 RCSB], [https://www.ebi.ac.uk/pdbsum/8t49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t49 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interactions, and vaccine priming of HCDR3-dominant bnAbs by germline-targeting immunogens has not been demonstrated in humans or outbred animals. In this work, immunization with N332-GT5, an HIV envelope trimer designed to target precursors of the HCDR3-dominant bnAb BG18, primed bnAb-precursor B cells in eight of eight rhesus macaques to substantial frequencies and with diverse lineages in germinal center and memory B cells. We confirmed bnAb-mimicking, HCDR3-dominant, trimer-binding interactions with cryo-electron microscopy. Our results demonstrate proof of principle for HCDR3-dominant bnAb-precursor priming in outbred animals and suggest that N332-GT5 holds promise for the induction of similar responses in humans. | |||
, PMID:38753769<ref>PMID:38753769</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8t49" style="background-color:#fffaf0;"></div> | ||
[[Category: Ozorowski | == References == | ||
[[Category: Torres | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human immunodeficiency virus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Macaca mulatta]] | |||
[[Category: Ozorowski G]] | |||
[[Category: Torres JL]] | |||
[[Category: Ward AB]] | |||
Latest revision as of 09:09, 4 June 2025
MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab
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