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| <StructureSection load='6y3k' size='340' side='right'caption='[[6y3k]]' scene=''> | | <StructureSection load='6y3k' size='340' side='right'caption='[[6y3k]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6y3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corylus_avellana Corylus avellana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3K FirstGlance]. <br> | | <table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3K FirstGlance]. <br> |
| </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3k OCA], [https://pdbe.org/6y3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3k RCSB], [https://www.ebi.ac.uk/pdbsum/6y3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3k ProSAT]</span></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3k OCA], [https://pdbe.org/6y3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3k RCSB], [https://www.ebi.ac.uk/pdbsum/6y3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3k ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function ==
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| [https://www.uniprot.org/uniprot/Q9FPK3_CORAV Q9FPK3_CORAV]
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In this work we describe the NMR solution structures of these proteins and provide an in-depth study of their biophysical properties. Despite sharing highly similar three-dimensional structures, the four isoforms exhibit remarkable differences regarding structural flexibility, hydrogen bonding and thermal stability. Our experimental data reveal an inverse relation between structural flexibility and IgE-binding in ELISA experiments, with the most flexible isoform having the lowest IgE-binding potential, while the isoform with the most rigid backbone scaffold displays the highest immunologic reactivity. These results point towards a significant entropic contribution to the process of antibody binding.
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| Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.,Fuhrer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M Sci Rep. 2021 Feb 18;11(1):4173. doi: 10.1038/s41598-021-83705-z. PMID:33603065<ref>PMID:33603065</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 6y3k" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Corylus avellana]]
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| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Fuehrer S]] | | [[Category: Fuehrer S]] |
