7lvf: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>~~[[7lvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Juglans_regia Juglans regia].~~ Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVF FirstGlance]. <br>

<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVF FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvf OCA], [https://pdbe.org/7lvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvf RCSB], [https://www.ebi.ac.uk/pdbsum/7lvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvf ProSAT]</span></td></tr>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvf OCA], [https://pdbe.org/7lvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvf RCSB], [https://www.ebi.ac.uk/pdbsum/7lvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvf ProSAT]</span></td></tr>

</table>

~~== Function ==~~

~~[https://www.uniprot.org/uniprot/VCL2_JUGRE VCL2_JUGRE] Seed storage protein.<ref>PMID:10589017</ref> <ref>PMID:21883278</ref> <ref>PMID:25388987</ref> <ref>PMID:30054513</ref>~~

~~<div style="background-color:#fffaf0;">~~

~~== Publication Abstract from PubMed ==~~

Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader sequences (LSs) of seed storage proteins. VBPs are defined by a common alpha-hairpin fold mediated by conserved CxxxCx(10-14)CxxxC motifs. Here, peanut and walnut VBPs were characterized as potential mediators of both peanut/walnut allergenicity and cross-reactivity despite their low ( approximately 17%) sequence identity. The structures of one peanut (AH1.1) and 3 walnut (JR2.1, JR2.2, JR2.3) VBPs were solved using solution NMR, revealing similar alpha-hairpin structures stabilized by disulfide bonds with high levels of surface similarity. Peptide microarrays identified several peptide sequences primarily on AH1.1 and JR2.1, which were recognized by peanut-, walnut-, and dual-allergic patient IgE, establishing these peanut and walnut VBPs as potential mediators of allergenicity and cross-reactivity. JR2.2 and JR2.3 displayed extreme resilience against endosomal digestion, potentially hindering epitope generation and likely contributing to their reduced allergic potential.

Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.,Foo ACY, Nesbit JB, Gipson SAY, Cheng H, Bushel P, DeRose EF, Schein CH, Teuber SS, Hurlburt BK, Maleki SJ, Mueller GA J Agric Food Chem. 2022 Feb 9. doi: 10.1021/acs.jafc.1c07225. PMID:35139305<ref>PMID:35139305</ref>

~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~

~~</div>~~

~~<div class="pdbe-citations 7lvf" style="background-color:#fffaf0;"></div>~~

~~== References ==~~

~~<references/>~~

__TOC__

</StructureSection>

~~[[Category: Juglans regia]]~~

[[Category: Large Structures]]

[[Category: DeRose EF]]

[[Category: Foo ACY]]

[[Category: Mueller GA]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='7lvf' size='340' side='right'caption='[[7lvf]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[7lvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Juglans_regia Juglans regia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVF FirstGlance]. <br>
+<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LVF FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvf OCA], [https://pdbe.org/7lvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvf RCSB], [https://www.ebi.ac.uk/pdbsum/7lvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvf ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lvf OCA], [https://pdbe.org/7lvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lvf RCSB], [https://www.ebi.ac.uk/pdbsum/7lvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lvf ProSAT]</span></td></tr>
 </table>
-== Function ==
-[https://www.uniprot.org/uniprot/VCL2_JUGRE VCL2_JUGRE] Seed storage protein.<ref>PMID:10589017</ref> <ref>PMID:21883278</ref> <ref>PMID:25388987</ref> <ref>PMID:30054513</ref>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader sequences (LSs) of seed storage proteins. VBPs are defined by a common alpha-hairpin fold mediated by conserved CxxxCx(10-14)CxxxC motifs. Here, peanut and walnut VBPs were characterized as potential mediators of both peanut/walnut allergenicity and cross-reactivity despite their low ( approximately 17%) sequence identity. The structures of one peanut (AH1.1) and 3 walnut (JR2.1, JR2.2, JR2.3) VBPs were solved using solution NMR, revealing similar alpha-hairpin structures stabilized by disulfide bonds with high levels of surface similarity. Peptide microarrays identified several peptide sequences primarily on AH1.1 and JR2.1, which were recognized by peanut-, walnut-, and dual-allergic patient IgE, establishing these peanut and walnut VBPs as potential mediators of allergenicity and cross-reactivity. JR2.2 and JR2.3 displayed extreme resilience against endosomal digestion, potentially hindering epitope generation and likely contributing to their reduced allergic potential.
-Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides.,Foo ACY, Nesbit JB, Gipson SAY, Cheng H, Bushel P, DeRose EF, Schein CH, Teuber SS, Hurlburt BK, Maleki SJ, Mueller GA J Agric Food Chem. 2022 Feb 9. doi: 10.1021/acs.jafc.1c07225. PMID:35139305<ref>PMID:35139305</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 7lvf" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Juglans regia]]
 [[Category: Large Structures]]
 [[Category: DeRose EF]]
 [[Category: Foo ACY]]
 [[Category: Mueller GA]]