7n23: Difference between revisions

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<StructureSection load='7n23' size='340' side='right'caption='[[7n23]]' scene=''>
<StructureSection load='7n23' size='340' side='right'caption='[[7n23]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7n23]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_anemone Conus anemone]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N23 FirstGlance]. <br>
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N23 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n23 OCA], [https://pdbe.org/7n23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n23 RCSB], [https://www.ebi.ac.uk/pdbsum/7n23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n23 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n23 OCA], [https://pdbe.org/7n23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n23 RCSB], [https://www.ebi.ac.uk/pdbsum/7n23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n23 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CA1AB_CONAN CA1AB_CONAN] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic toxin blocks rat alpha-3beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.3 nM) and alpha-7/CHRNA7 nAChRs (IC(50)=76 nM).<ref>PMID:14971903</ref>  This synthetic toxin blocks rat alpha-3-beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.2 nM).<ref>PMID:14971903</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conus anemone]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Conibear AC]]
[[Category: Conibear AC]]
[[Category: Lee HS]]
[[Category: Lee HS]]
[[Category: Rosengren KJ]]
[[Category: Rosengren KJ]]
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