5co1: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5co1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CO1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5co1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CO1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5co1 OCA], [https://pdbe.org/5co1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5co1 RCSB], [https://www.ebi.ac.uk/pdbsum/5co1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5co1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5co1 OCA], [https://pdbe.org/5co1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5co1 RCSB], [https://www.ebi.ac.uk/pdbsum/5co1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5co1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/PCD19_DANRE PCD19_DANRE] Calcium-dependent cell-adhesion protein (PubMed:21115806). Essential for the early stages of neurulation in the anterior neural plate (PubMed:19615992). Shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cadherin cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex (PubMed:21115806, PubMed:22184198, PubMed:33004519). Functions with cdh2 to coordinate cell adhesion and cell movements during neurulation (PubMed:21115806). Contributes to neural progenitor cell patterning with cdh2 by promoting homophilic cell interactions (PubMed:33004519). Regulates the columnar organization of neurons in the optic tectum (PubMed:26598617).<ref>PMID:19615992</ref> <ref>PMID:21115806</ref> <ref>PMID:22184198</ref> <ref>PMID:26598617</ref> <ref>PMID:33004519</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Latest revision as of 08:15, 4 March 2026
Crystal Structure of Zebrafish Protocadherin-19 EC3-4
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