8jp0: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8jp0 is ~~ON HOLD~~

==structure of human sodium-calciumexchanger NCX1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8jp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JP0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8JP0 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKY:2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline'>EKY</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8jp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jp0 OCA], [https://pdbe.org/8jp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jp0 RCSB], [https://www.ebi.ac.uk/pdbsum/8jp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jp0 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NAC1_HUMAN NAC1_HUMAN] Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity).[UniProtKB:P70414]<ref>PMID:11241183</ref> <ref>PMID:1374913</ref> <ref>PMID:1476165</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Dong Y]]

[[Category: Zhao Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8jp0 is ON HOLD
+==structure of human sodium-calciumexchanger NCX1==
+<StructureSection load='8jp0' size='340' side='right'caption='[[8jp0]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8jp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JP0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKY:2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline'>EKY</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jp0 OCA], [https://pdbe.org/8jp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jp0 RCSB], [https://www.ebi.ac.uk/pdbsum/8jp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jp0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAC1_HUMAN NAC1_HUMAN] Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity).[UniProtKB:P70414]<ref>PMID:11241183</ref> <ref>PMID:1374913</ref> <ref>PMID:1476165</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Dong Y]]
+[[Category: Zhao Y]]