8pfq: Difference between revisions
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New page: '''Unreleased structure''' The entry 8pfq is ON HOLD Authors: Description: Category: Unreleased Structures |
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==RNA structure with 1-methylpseudouridine, P1 space group== | |||
<StructureSection load='8pfq' size='340' side='right'caption='[[8pfq]], [[Resolution|resolution]] 1.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8pfq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PFQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.01Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B8H:[(2~{R},3~{S},4~{R},5~{S})-5-[1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+dihydrogen+phosphate'>B8H</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pfq OCA], [https://pdbe.org/8pfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pfq RCSB], [https://www.ebi.ac.uk/pdbsum/8pfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pfq ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
All widely used mRNA vaccines against COVID-19 contain in their sequence 1-methylpseudouridine (m1Psi) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 A, respectively) of one such double-stranded 12-mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the X-ray structure of 1-methyl-pseudouridine itself was determined. | |||
RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.,Nievergelt P, Berliat F, McAuley KE, Dorgan CR, van Well RM, Thorn A, Spingler B ChemMedChem. 2024 Apr 2;19(7):e202300600. doi: 10.1002/cmdc.202300600. Epub 2024 , Feb 29. PMID:38235959<ref>PMID:38235959</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 8pfq" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: McAuley K]] | |||
[[Category: Nievergelt P]] | |||
[[Category: Spingler B]] | |||
[[Category: Thorn A]] | |||
Latest revision as of 14:47, 6 November 2024
RNA structure with 1-methylpseudouridine, P1 space group
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