8pm6: Difference between revisions
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The entry | ==Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs== | ||
<StructureSection load='8pm6' size='340' side='right'caption='[[8pm6]], [[Resolution|resolution]] 3.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8pm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PM6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.22Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pm6 OCA], [https://pdbe.org/8pm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pm6 RCSB], [https://www.ebi.ac.uk/pdbsum/8pm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pm6 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bang-Sorensen R]] | |||
[[Category: Irobalieva RN]] | |||
[[Category: Kowal J]] | |||
[[Category: Lancien L]] | |||
[[Category: Liu H]] | |||
[[Category: Locher KP]] | |||
[[Category: Ni D]] | |||
[[Category: Nosol K]] | |||
[[Category: Stahlberg H]] | |||
[[Category: Stieger B]] | |||
Latest revision as of 16:54, 9 July 2025
Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
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