Aldolase: Difference between revisions
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<StructureSection load='3mmt' size='340' side='right' caption='Fructose 1,6-bisphosphate aldolase tetramer complex with fructose 1,6-bisphosphate, [[3mmt]]|' scene=''> | <StructureSection load='3mmt' size='340' side='right' caption='Fructose 1,6-bisphosphate aldolase tetramer complex with fructose 1,6-bisphosphate, [[3mmt]]|' scene=''> | ||
'''Retro aldolase''' is an aldolase designed by directed evolution. | |||
=Aldolase class I= | =Aldolase class I= | ||
'''Fructose-6-phosphate aldolase''' catalyzes the cleavage of fructose-6-phosphate<ref>PMID:11120740</ref>.<br /> | '''Fructose-6-phosphate aldolase''' catalyzes the cleavage of fructose-6-phosphate<ref>PMID:11120740</ref>.<br /> | ||
'''Fructose-1,6-bisphosphate aldolase''' (FBPA) catalyzes the fourth step of glycolysis<ref>PMID:34458323</ref>.<br /> | |||
'''Deoxyribose-phosphate aldolase''' converts 2-deoxy-D-ribose-5-phosphate into glyceraldehyde 3-phosphate and acetaldehyde<ref>PMID:25229427</ref>.<br /> | '''Deoxyribose-phosphate aldolase''' converts 2-deoxy-D-ribose-5-phosphate into glyceraldehyde 3-phosphate and acetaldehyde<ref>PMID:25229427</ref>.<br /> | ||
'''Dihydroneopterin aldolase''' catalyzes the conversion of 7,8-dihydropterin to 6-hydroxymethyl-7,8-dihydropterin. It is part of the folate synthesis <ref>PMID:15107504</ref>.<br /> | '''Dihydroneopterin aldolase''' catalyzes the conversion of 7,8-dihydropterin to 6-hydroxymethyl-7,8-dihydropterin. It is part of the folate synthesis <ref>PMID:15107504</ref>.<br /> | ||
'''Sialic acid aldolase''' catalyzes the condensation of pyruvate and N-acetylmannosamine<ref>PMID:11674166</ref>. | '''Sialic acid aldolase''' catalyzes the condensation of pyruvate and N-acetylmannosamine<ref>PMID:11674166</ref>. See [[N-acetylneuraminate lyase]].<br /> | ||
'''Oxoadipate aldolase''' catalyzes the last step of the bacterial protocatechuate 4,5-cleavage pathway<ref>PMID:20843800</ref>.<br /> | '''Oxoadipate aldolase''' catalyzes the last step of the bacterial protocatechuate 4,5-cleavage pathway<ref>PMID:20843800</ref>.<br /> | ||
'''Oxovalerate aldolase''' catalyzes the conversion of 4-hydroxy-2-oxopentanoate to acetaldehyde and pyruvate<ref>PMID:8419288</ref>.<br /> | '''Oxovalerate aldolase''' catalyzes the conversion of 4-hydroxy-2-oxopentanoate to acetaldehyde and pyruvate<ref>PMID:8419288</ref>.<br /> | ||
'''2-keto-deoxydephosphogluconate aldolase''' catalyzes the cleavage of 2-keto-deoxydephosphogluconate<ref>PMID:12876349</ref>.<br /> | '''2-keto-deoxydephosphogluconate aldolase''' catalyzes the cleavage of 2-keto-deoxydephosphogluconate<ref>PMID:12876349</ref>.<br /> | ||
'''Phospho-2-dehydro-3-deoxyheptonate aldolase''' participates in the phthalide biosynthesis<ref>PMID:35845641</ref>.<br /> | |||
=Aldolase class II. Metal-dependent aldolase= | =Aldolase class II. Metal-dependent aldolase= | ||
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'''Oxoglutarate aldolase''' catalyzes the cleavage of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate. It belongs to the hydroxyproline degradation pathway<ref>PMID:21998747</ref>.<br /> | '''Oxoglutarate aldolase''' catalyzes the cleavage of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate. It belongs to the hydroxyproline degradation pathway<ref>PMID:21998747</ref>.<br /> | ||
'''Threonine aldolase''' catalyzes the cleavage of threonine into glycine and acetaldehyde. It is part of the glycine, serine and threonine metabolism pathway<ref>PMID:13449064</ref>.<br /> | '''Threonine aldolase''' catalyzes the cleavage of threonine into glycine and acetaldehyde. It is part of the glycine, serine and threonine metabolism pathway<ref>PMID:13449064</ref>.<br /> | ||
'''Rhamnulose-1-phosphate aldolase''' participates in the degradation pathway of L-rhamnose <ref>PMID:18085797</ref>.<br /> | |||
'''4-hydroxy-2-oxoglutarate aldolase''' catalyzes the cleavage of 4-hydroxy-2-oxoglutarate to pyruvate and glyoxylate It is part of the hydroxyproline degradation pathway<ref>PMID:21998747</ref>.<br /> | |||
'''Hydroxyaspartate aldolase''' catalyzes the cleavage of hydroxyaspartate to glyoxylate and glycine<ref>PMID:12835921</ref>.<br /> | |||
'''Phenylserine aldolase''' catalyzes the cleavage of L-3-phenylserine to benzaldehyde and glycine<ref>PMID:16085854</ref>.<br /> | |||
= Fructose Bisphosphate Aldolase = | = Fructose Bisphosphate Aldolase = | ||
==Introduction and Structure== | ==Introduction and Structure== | ||
