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| [[Image:1lbd.gif|left|200px]]<br /> | | #REDIRECT [[6hn6]] This PDB entry is obsolete and replaced by 6hn6 |
| <applet load="1lbd" size="450" color="white" frame="true" align="right" spinBox="true"
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| caption="1lbd, resolution 2.7Å" />
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| '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br />
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| ==Overview==
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| The crystal structure of the human retinoid-X receptor RXR-alpha, ligand-binding domain reveals a previously undiscovered fold of an, antiparallel alpha-helical sandwich, packed as dimeric units. Two helices, and one loop form the homodimerization surface, and hydrophobic heptad, repeats participate in stabilizing the fold. The existence of a, ligand-binding pocket is proposed that would allow 9-cis retinoic acid to, interact with different functional modules, including the AF-2 activating, domain. Several lines of evidence indicate that the overall structure is a, prototype fold of ligand-binding domains of nuclear receptors.
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| ==About this Structure==
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| 1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
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| ==Reference==
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| Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7760929 7760929]
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| [[Category: Homo sapiens]]
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| [[Category: Single protein]]
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| [[Category: Bourguet, W.]]
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| [[Category: Moras, D.]]
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| [[Category: SPINE, Structural.Proteomics.in.Europe.]]
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| [[Category: nuclear receptor]]
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| [[Category: spine]]
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| [[Category: structural genomics]]
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| [[Category: structural proteomics in europe]]
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| [[Category: transcription factor]]
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| ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:58:28 2007''
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