Netrin receptor: Difference between revisions
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<StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | <StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | ||
== Function == | == Function == | ||
'''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>. | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. | ||
*Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | |||
*'''UNC-5B receptor''' or '''UNC-5H2''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>. | |||
*'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>. | |||
== Disease == | == Disease == | ||
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**[[4v2a]] – hUNC5A ectodomain <BR /> | **[[4v2a]] – hUNC5A ectodomain <BR /> | ||
*Netrin receptor UNC5B | *Netrin receptor UNC5B or UNC5H2 | ||
**[[6ool]] – mUNC5B ectodomain<BR /> | **[[6ool]] – mUNC5B ectodomain<BR /> | ||
**[[1wmg]] – mUNC5B death domain <BR /> | |||
**[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | **[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | ||
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**[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | **[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
