8pyw: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 8pyw is ON HOLD~~

==Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.==

~~Authors: Feracci, M., Chazot, A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8pyw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PYW OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8PYW FirstGlance].

~~Description:~~ Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.553Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IF9:[[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl]+dihydrogen+phosphate'>IF9</scene></td></tr>

[[Category: Chazot, A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8pyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pyw OCA], [https://pdbe.org/8pyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pyw RCSB], [https://www.ebi.ac.uk/pdbsum/8pyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pyw ProSAT]</td></tr>

[[Category: Feracci, M]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/NDKB_HUMAN NDKB_HUMAN] Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.<ref>PMID:15249197</ref> <ref>PMID:20946858</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chazot A]]

[[Category: Feracci M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8pyw is ON HOLD
+==Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.==
+<StructureSection load='8pyw' size='340' side='right'caption='[[8pyw]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-Authors: Feracci, M., Chazot, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pyw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PYW FirstGlance]. <br>
-Description: Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.553&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IF9:[[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl]+dihydrogen+phosphate'>IF9</scene></td></tr>
-[[Category: Chazot, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pyw OCA], [https://pdbe.org/8pyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pyw RCSB], [https://www.ebi.ac.uk/pdbsum/8pyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pyw ProSAT]</span></td></tr>
-[[Category: Feracci, M]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NDKB_HUMAN NDKB_HUMAN] Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.<ref>PMID:15249197</ref> <ref>PMID:20946858</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chazot A]]
+[[Category: Feracci M]]