Peregrin: Difference between revisions

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== '''Overview''' ==

'''Peregrin''', also known as Bromodomain and PHD Finger-containing 1 ('''BRPF1''') is a 137 kDa protein that plays a versatile role in epigenetic signaling events. It contains three chromatin reader domains, including a <scene name='91/910741/Apo_bromodomain/1'>bromodomain</scene>, <scene name='91/910741/Apo_pzp/1'>PZP domain</scene> (two PHD fingers separated by a Zinc Knuckle), and '''proline-tryptophan-tryptophan-proline (<scene name='91/910741/Pwwp_unliganded/1'>PWWP</scene>) domain''' (from N to C terminus)<ref name="Yan">PMID:27939640</ref>. Through these three domains, it is capable of recognizing both modified and unmodified histones, as well as non-specifically binding DNA <ref name="Klein">PMID:31711755</ref>,<ref name="Glass1">PMID:24333487</ref>. BRPF1 carries out its function as a component of the MOZ (monocytic leukemic zinc-finger protein) histone acetyltransferase (HAT) complex <ref name="Obi">PMID:33554132</ref>. This complex is involved in the regulation of gene expression, particularly those involved with skeletal development, hematopoiesis, and neurodevelopmental processes <ref>PMID:19254709</ref>,<ref>PMID:27500495</ref>,<ref name="Klein" />. Accordingly, it has the greatest tissue distribution in the bone marrow and brain.

'''Peregrin''', also known as '''Bromodomain and PHD Finger-containing 1''' ('''BRPF1''') is a 137 kDa protein that plays a versatile role in epigenetic signaling events. It contains three chromatin reader domains, including a <scene name='91/910741/Apo_bromodomain/1'>bromodomain</scene>, <scene name='91/910741/Apo_pzp/1'>PZP domain</scene> (two PHD fingers separated by a Zinc Knuckle), and '''proline-tryptophan-tryptophan-proline (<scene name='91/910741/Pwwp_unliganded/1'>PWWP</scene>) domain''' (from N to C terminus)<ref name="Yan">PMID:27939640</ref>. Through these three domains, it is capable of recognizing both modified and unmodified histones, as well as non-specifically binding DNA <ref name="Klein">PMID:31711755</ref>,<ref name="Glass1">PMID:24333487</ref>. BRPF1 carries out its function as a component of the MOZ (monocytic leukemic zinc-finger protein) histone acetyltransferase (HAT) complex <ref name="Obi">PMID:33554132</ref>. This complex is involved in the regulation of gene expression, particularly those involved with skeletal development, hematopoiesis, and neurodevelopmental processes <ref>PMID:19254709</ref>,<ref>PMID:27500495</ref>,<ref name="Klein" />. Accordingly, it has the greatest tissue distribution in the bone marrow and brain.

== '''PZP Domain''' ==

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==Peregrin PDB structures==

[[Peregrin 3D structures]]

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

* Peregrin; Domains – PZP 274-450; bromodomain 626-740; PWWP 1079-1207

**[[3l42]] – hBRPF1 PWWP domain - human

**[[5erc]] – hBRPF1 PZP domain

**[[4lc2]], [[7c4i]] – hBRPF1 bromodomain

**[[~~2d9e]] – hBRPF1 bromodomain - NMR ~~

* Peregrin ~~complexes~~

**[[5ewv]], [[5eww]], [[5c89]], [[5g4r]], [[5g4s]], [[5em3]], [[5ev9]], [[5eva]], [[5ewh]], [[5c85]], [[5c87]], [[5d7x]], [[5dy7]], [[5d7a]], [[5dyc]], [[5e3d]], [[5e3g]], [[5epr]], [[5eps]], [[5eq1]], [[5etb]], [[5etd]], [[5ewc]], [[5ewd]], [[5ffy]], [[5c7n]], [[4uye]], [[5dya]] – hBRPF1 bromodomain + ligand

**[[5ffv]], [[5ffw]], [[4qyd]], [[4qyl]] – hBRPF1 bromodomain + histone peptide

**[[2rs9]] – hBRPF1 bromodomain + histone peptide - NMR

**[[3mo8]], [[2x4w]], [[2x4x]], [[2x4y]], [[2x35]] – hBRPF1 PWWP domain + histone peptide

**[[5fg5]], [[5fg4]], [[5myg]] – hBRPF1 bromodomain + chemical probe

**[[5t4u]], [[5t4v]], [[5mwg]], [[5mwh]], [[5mwz]], [[5o4s]], [[5o4t]], [[5o55]], [[5o5a]], [[5o5f]], [[5o5h]], [[5ov8]], [[5owa]], [[5owb]], [[5owe]], [[6ekq]] – hBRPF1 bromodomain + inhibitor

**[[5c6s]] ~~– hBRPF1 PWWP domain + ligand ~~

}}

== '''References''' ==

[[Category:Topic Page]]

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 == '''Overview''' ==
-'''Peregrin''', also known as Bromodomain and PHD Finger-containing 1 ('''BRPF1''') is a 137 kDa protein that plays a versatile role in epigenetic signaling events. It contains three chromatin reader domains, including a <scene name='91/910741/Apo_bromodomain/1'>bromodomain</scene>, <scene name='91/910741/Apo_pzp/1'>PZP domain</scene> (two PHD fingers separated by a Zinc Knuckle), and '''proline-tryptophan-tryptophan-proline (<scene name='91/910741/Pwwp_unliganded/1'>PWWP</scene>) domain''' (from N to C terminus)<ref name="Yan">PMID:27939640</ref>. Through these three domains, it is capable of recognizing both modified and unmodified histones, as well as non-specifically binding DNA <ref name="Klein">PMID:31711755</ref>,<ref name="Glass1">PMID:24333487</ref>. BRPF1 carries out its function as a component of the MOZ (monocytic leukemic zinc-finger protein) histone acetyltransferase (HAT) complex <ref name="Obi">PMID:33554132</ref>. This complex is involved in the regulation of gene expression, particularly those involved with skeletal development, hematopoiesis, and neurodevelopmental processes <ref>PMID:19254709</ref>,<ref>PMID:27500495</ref>,<ref name="Klein" />. Accordingly, it has the greatest tissue distribution in the bone marrow and brain.
+'''Peregrin''', also known as '''Bromodomain and PHD Finger-containing 1''' ('''BRPF1''') is a 137 kDa protein that plays a versatile role in epigenetic signaling events. It contains three chromatin reader domains, including a <scene name='91/910741/Apo_bromodomain/1'>bromodomain</scene>, <scene name='91/910741/Apo_pzp/1'>PZP domain</scene> (two PHD fingers separated by a Zinc Knuckle), and '''proline-tryptophan-tryptophan-proline (<scene name='91/910741/Pwwp_unliganded/1'>PWWP</scene>) domain''' (from N to C terminus)<ref name="Yan">PMID:27939640</ref>. Through these three domains, it is capable of recognizing both modified and unmodified histones, as well as non-specifically binding DNA <ref name="Klein">PMID:31711755</ref>,<ref name="Glass1">PMID:24333487</ref>. BRPF1 carries out its function as a component of the MOZ (monocytic leukemic zinc-finger protein) histone acetyltransferase (HAT) complex <ref name="Obi">PMID:33554132</ref>. This complex is involved in the regulation of gene expression, particularly those involved with skeletal development, hematopoiesis, and neurodevelopmental processes <ref>PMID:19254709</ref>,<ref>PMID:27500495</ref>,<ref name="Klein" />. Accordingly, it has the greatest tissue distribution in the bone marrow and brain.
 == '''PZP Domain''' ==
@@ Line 35: / Line 35: @@
 ==Peregrin PDB structures==
+[[Peregrin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Peregrin; Domains – PZP 274-450; bromodomain 626-740; PWWP 1079-1207
-**[[3l42]] – hBRPF1 PWWP domain - human<br />
-**[[5erc]] – hBRPF1 PZP domain<br />
-**[[4lc2]], [[7c4i]]  – hBRPF1 bromodomain <br />
-**[[2d9e]]  – hBRPF1 bromodomain - NMR<br />
-* Peregrin complexes
-**[[5ewv]], [[5eww]], [[5c89]], [[5g4r]], [[5g4s]], [[5em3]], [[5ev9]], [[5eva]], [[5ewh]], [[5c85]], [[5c87]], [[5d7x]], [[5dy7]], [[5d7a]], [[5dyc]], [[5e3d]], [[5e3g]], [[5epr]], [[5eps]], [[5eq1]], [[5etb]], [[5etd]], [[5ewc]], [[5ewd]], [[5ffy]], [[5c7n]], [[4uye]], [[5dya]]  – hBRPF1 bromodomain + ligand <br />
-**[[5ffv]], [[5ffw]], [[4qyd]], [[4qyl]]  – hBRPF1 bromodomain + histone peptide<br />
-**[[2rs9]]  – hBRPF1 bromodomain + histone peptide - NMR<br />
-**[[3mo8]], [[2x4w]], [[2x4x]], [[2x4y]], [[2x35]]  – hBRPF1 PWWP domain + histone peptide<br />
-**[[5fg5]], [[5fg4]], [[5myg]]  – hBRPF1 bromodomain + chemical probe<br />
-**[[5t4u]], [[5t4v]], [[5mwg]], [[5mwh]], [[5mwz]], [[5o4s]], [[5o4t]], [[5o55]], [[5o5a]], [[5o5f]], [[5o5h]], [[5ov8]], [[5owa]], [[5owb]], [[5owe]], [[6ekq]] – hBRPF1 bromodomain + inhibitor<br />
-**[[5c6s]]  – hBRPF1 PWWP domain + ligand <br />
-}}
 == '''References''' ==
 <references/>
 [[Category:Topic Page]]