8q6r: Difference between revisions
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New page: '''Unreleased structure''' The entry 8q6r is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Structure of complement FP in complex with the TPP-3077 VHH== | |||
<StructureSection load='8q6r' size='340' side='right'caption='[[8q6r]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8q6r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q6R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q6r OCA], [https://pdbe.org/8q6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q6r RCSB], [https://www.ebi.ac.uk/pdbsum/8q6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q6r ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PROP_HUMAN PROP_HUMAN] Defects in CFP are the cause of properdin deficiency (PFD) [MIM:[https://omim.org/entry/312060 312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).<ref>PMID:8871668</ref> <ref>PMID:9710744</ref> <ref>PMID:10909851</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PROP_HUMAN PROP_HUMAN] A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | |||
[[Category: Andersen GR]] | |||
[[Category: Pedersen DV]] | |||
Latest revision as of 05:18, 28 August 2024
Structure of complement FP in complex with the TPP-3077 VHH
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