1m7b: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1m7b.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_1m7b", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_1m7b|  PDB=1m7b  |  SCENE=  }}
'''Crystal structure of Rnd3/RhoE: functional implications'''


==Crystal structure of Rnd3/RhoE: functional implications==
<StructureSection load='1m7b' size='340' side='right'caption='[[1m7b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1m7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M7B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7b OCA], [https://pdbe.org/1m7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m7b RCSB], [https://www.ebi.ac.uk/pdbsum/1m7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m7b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RND3_HUMAN RND3_HUMAN] Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/1m7b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m7b ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.


==Overview==
Crystal structure of Rnd3/RhoE: functional implications.,Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169<ref>PMID:12163169</ref>
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1M7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7B OCA].
</div>
<div class="pdbe-citations 1m7b" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12163169 12163169]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ahmadian, M R.]]
[[Category: Ahmadian MR]]
[[Category: Blumenstein, L.]]
[[Category: Blumenstein L]]
[[Category: Fiegen, D.]]
[[Category: Fiegen D]]
[[Category: Stege, P.]]
[[Category: Stege P]]
[[Category: Vetter, I R.]]
[[Category: Vetter IR]]
[[Category: Small gtpase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:43:30 2008''
Retrieved from "https://proteopedia.org/1m7b"